Hey I’m diabetic the doctors said I’m neither 1 or 2 and expect it to be mody but they prescribed me mody and I was wondering if anyone has taken that and how has it worked for them. So far it’s been good for me just a lot of lows. I’m more new to this diabetes stuff but it’s all genetic so trying t
Glyburide is a sulfonylurea (SU) more like insulin than other oral meds. It gooses your pancreas to produce more insulin, and that works, as long as your pancreas can supply. It's no use in T1, but it can stimulate more than normal insulin release, to overcome insulin resistance (=T2) in the tissues.
MODY is a pretty specific - an inherited condition so you usually have at least one parent with it?
With MODY, your pancreas still produces insulin, you just lack the signal to make it release. SUs reinforce the signal. Your insulin is normal, your cells are normal (no insulin resistance), so SUs may be all you ever need.
Other meds work by influencing other organs and your muscle cells, and meds like Jardiance would only be useful if your SUs aren't effective enough.
Ahhh ok wow that’s starting to make a lot o sense. So my dad is diabetic and he passed the diabetic gene off to me and sister because he had a 50/50 chance of passing it off.
My dad tried taking glyburide but it didn’t work for him but he also needs to take ridiculous amounts of insulin so I think his pancreas doesn’t work at all.
Do you think it’d be smart to get genetic testing done to know for sure if I have mody or not or does it not really matter if I know or not?
MODY3 here with father/uncles/brother/son all MODY3 as well. I believe my dad was on glyburide for years before being totally insulin dependent in his 70s. Yes, the right diagnosis and oral medications are greatly beneficial as our bodies are different from T1 and T2. There are many types of MODY as well, with different treatments. Having had it since 1968 and being misdiagnosed in various ways until 2009, I can advise having an endo that has experience in MODY is really important.
Hmm alright that also helps a ton. I’m guessing my dad was like me when he was my age and after a while of not taking the best care of his diabetes has become insulin dependent.
Do you know if becoming insulin dependent is almost inevitable or does it just depend on person? At least when referring to Mody.
I'm not a doctor, just someone who has lived with this in my family for a long, long time. And there are so many types of MODY as well, and types of treatment, and they differ in their complications. My dad and have always handled it well with tighter control than may have been necessary, perhaps. He and I both had many years without things like home glucose monitoring or CGMs even being available. But in doing so, my dad lived about 20 years longer than his other 4 brothers. Still ended up totally insulin dependent. I'm on a mix of oral meds and small insulin doses after 58 years of the disease. I prefer it as it allows me a bit more flexibility, and SUs were hard to manage my lows. My a1cs rarely go over 6.5, and mostly below 6.0. My type of MODY is at very high risk of cardiovas
Alright I guess it's important I pin point it so I can make sure I'm getting correct treatment and stuff but for right now the oral medication and small dosage work a lot and I can still do high school sports and stuff fine
Honestly, the fact that your care provider is aware you might have MODY is a good sign:).
Sorry about your Dad. Sounds like he progressed from MODY to T1 but I don't have experience with that.
smart to get genetic testing done
I'd be surprised if they haven't already. But you're implying they've tested for T1 antibodies and decided it isn't T1. In that case, SUs are appropriate for either type of DM.
Ask if they've tested for MODY. I'm sure they would if your insurance covers it.
Alright next doctors visit I’ll ask then I’ll see how much it’ll be to get done because I’m pretty sure genetic testing is expensive but not too sure.
Thank you this information has actually help me a ton
genetic testing is expensive
Ask yourself if it will change anything right now.
And hey - ask if they've tested your Dad.
I don't think it will to be honest at least the doctors said it wasn't that Importnat at the moment.
And next time I see my dad ill ask thank you!
Yup.
Especially if your dad tested positive for the gene problem. No hurry testing yours.